Chapter 2 - Epithelium
Epithelium forms continuous sheets of cells that line internal surfaces and cover the external surface of the body. It acts as a selective barrier that protects tissues. A basement membrane separates the epithelium from underlying connective tissue.
Epithelium is classified based on three criteria:
- Number of cell layers (single or compound)
- Shape of surface cells (squamous, cuboidal or columnar)
- Specializations (cilia, keratin or goblet cells)
Epithelial cells are polarized:
- Apical domain - surface that faces the lumen or the external environment
- Microvilli (brush border), cilia, stereocilia
- Lateral domain - surfaces that face the sides of adjacent cells
- Tight junctions (zona occludens), adherens junction (zona adherens), desmosomes (macula adherens), gap junctions
- Basal domain - surface that attaches to the basement membrane
- Basement membrane, hemidesmosomes
Epithelium does not contain blood vessels and receives nourishment via diffusion from the underlying connective tissue.
Glands are formed by the down growth of an epithelium into the underlying connective tissue.
It is not necessary to learn the names of specific tissues for this chapter, but rather learn to recognize variations in epithelia.
Simple Squamous Epithelium
Simple squamous epithelium consists of a single layer of flattened cells in contact with the basement membrane. The thinness of these cells facilitates the selective transfer of materials (e.g., gases, fluids or nutrients) across the epithelium.
Simple Cuboidal Epithelium
Simple cuboidal epithelium consists of a single layer of cuboidal cells. This epithelium is often associated with absorption, secretion or excretion of waste matter.
Simple Columnar Epithelium
Simple columnar epithelium consists of a single layer of cells that are taller than they are wide. This epithelium is often associated with absorption or secretion.
Small Intestine
Gallbladder
Pseudostratified Epithelium Epithelium
Pseudostratified epithelium appears to be stratified because the nuclei of the epithelial cells are at different levels, but every cell is in contact the basement membrane. The epithelial cells vary in height.
Stratified Squamous Epithelium
Stratified squamous epithelium has multiple layers of cells becoming flattened as they move from the basal layer to the apical layers. It provides protection from abrasion and is keratinized on the external surface of the body.
Cilia and Microvilli
Cilia and microvilli are two specializations frequently found on the lumenal surface of simple columnar epithelia.
Intercellular Junctions
Lateral specializations between individual epithelial cells of an epithelium. Those near the apical surface are Known as the junctional complex by Electron Microscopy | Histology and terminal bar by light microscopy.
Examples of intercellular junctions in the simple columnar epithelium of the small intestine.
