Histology Guide

virtual histology laboratory

Chapter 5 - Cartilage and Bone

Cartilage and bone are connective tissue specialized for support. Cartilage occurs where flexibility is required, while bone resists deformation.


Cartilage Histogenesis

Chondrogenesis is the process by which condensed mesenchyme tissue forms cartilage.

MH 020b Pig Snout Fetal


Three types of cartilage can be distinguished based on their composition of fibers and ground substance: hyaline cartilage, elastic cartilage and fibrocartilage.

Hyaline Cartilage

Hyaline cartilage contains an abundant ground substance with fibers of type II collagen.

MH 136 Trachea

MH 046 Hyaline Articular Cartilage

Elastic Cartilage

Elastic cartilage contains abundant elastic tissue with fibers of type II collagen.

MH 038-039 Epiglottis


Fibrocartilage contains extensive amounts of type I collagen and relatively few chondrocytes.

MH 040 Intervertebral Disk


Bone is hard and rigid because of mineralization. It forms the supportive framework (skeleton) for the body. Morphologically, bone is organized into two types: compact bone and spongy (cancellous or trabecular) bone.


The basic structural unit of bone is the osteon.

MH 043 Cancellous and Compact Bone


MH 045 Bone


MH 044 Ground Bone

MHS 202 Ground Bone

(Schmorl's stain)

MHS 233 Ground Bone

(India ink)

Intramembranous Bone Formation

Intramembranous bone formation occurs within organizing centers of mesenchyme that differentiate into osteoblasts and then osteocytes. (It does not require a collagen model.)

MH 046 Bone Development


MH 020b Fetal Pig Snout

MHS 242 Face Embryo

Endochondral Bone Formation

Endochondral bone formation starts with a cartilaginous model. It occurs at the epiphyseal plate of long bones.

MH 029b Bone


MH 046 Bone Development


MHS 203 Bone


Tooth Development

MH 020a Fetal Pig Snout