Histology Guide virtual histology laboratory

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200 Photographs

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Histology Guide

Chapter 8 - Hematopoiesis

Hematopoiesis is the formation of blood cell components. It occurs within the spongy portions of bones in adults.

Bone Marrow

Bone marrow is composed of hematopoetic cells, adipose tissue, and supportive stromal cells.

slide

MHS 304 Bone Marrow

(Hematoxylin & Eosin)

Bone Marrow Smear

Similar to blood smears, bone marrow smears separates the individual cells so their morphology can be more easily examined.

slide

MH 034a Bone Marrow Smear

(Wright's stain)

HEMATOPOIESIS

Blood cell development is shown using a single, high-resolution 60x scan from the zone of best morphology of a bone marrow smear. This allows the morphology and staining characteristics of different cell types to be easily compared.

Erythropoiesis

Erythropoesis is the formation of red blood cells. Granules are never seen in the lineage of red blood cells.

slide

MH 034bhr Red Blood Cell Development

(Wright's stain)

Granulopoiesis

Granulopoesis is the formation of white blood cells (leukocytes). Cells in the lineage of white blood cells contain azure granules (lysosomes) and in their later stages azure and specific granules. The specific granules are lightly stained in neutrophils, eosinophilic in eosinophils, and basophilic in basophils.

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MH 034bhr Neutrophil Development

(Wright's stain)

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MH 034bhr Eosinophil Development

(Wright's stain)

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MH 034bhr Basophil Development

(Wright's stain)

Agranlocytes

Agranulocytes are white blood cells (leukocytes) with an absence of granules in their cytoplasm.

slide

MH 034bhr Lymphocytes

(Wright's stain)

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MH 034bhr Plasma Cell

(Wright's stain)

slide

MH 034bhr Monocyte

(Wright's stain)

Thrombopoiesis

Thrombopoiesis is the formation of platelets. The largest cells found in bone marrow are megakaryocytes which give rise to pletelets.

slide

MH 034a/MH 034bhr Megakaryocyte and Platelet Formation

(Wright's stain)

REVIEW

This diagram allows the morphology and staining characteristics of different cell types to be compared.

slide

MH 034bhr Bone Marrow Smear

(Wright's stain)

ADDITIONAL EXAMPLES

Viewing of these slides is not required. However, they demonstrate the variability seen between different preparations of bone marrow smears.

slide

MH 034f Bone Marrow Smear (osteoclast)

(Wright's stain)

slide

MH 034ahr Bone Marrow Smear

(Wright's stain)

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MH 034dhr Bone Marrow Smear

(Wright's stain)

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MH 034ehr Bone Marrow Smear

(Wright's stain)

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MH 034fhr Bone Marrow Smear

(Wright's stain)