Stomach fixed after perfusion of a dye (red colloid) through the peripheral vascular system. This section shows a single ruga (plural, rugae) from the fundic stomach. Both the arterial supply and venous drainage of the mucosa are filled with the dye.
Blood travels upward from arterioles through a meshwork of mucosal capillaries that drain downward through mucosal venules. The larger arterial and venous vessels are found between the base of the glands and the muscularis mucosae.
The boundary between gastric pits and fundic glands in the mucosa can be identified by differences in blood supply.
Gastric Pits - sparse network of blood vessels found between the pits
Fundic Glands - surrounded by a dense, polygonal meshwork of blood vessels
This reflects the high metabolic activity of parietal cells when pumping hydrochloric acid (HCl) into the lumen of the stomach.