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Granulocytes develop from the multipotential myeloid stem cell (CFU-GEMM) which differentiates into lineage-specific progenitor cells.
Neutrophil progenitor cells (CFU-G)
Eosinophil progenitor cells (CFU-Eo)
Basophil progenitor cells (CFU-Baso)
Myeloblasts are produced from these progenitor cells under the influence of cytokines. Myeloblasts are the first recognizable precursor of granulocytes.
Large cells (12 to 18 µm diameter)
Large, round or oval nucleus (85 to 90% of cell) of euchromatin (fine, granular pattern)
Small amount of cytoplasm that is pink-blue to light blue
No granules
Capable of mitosis
Myeloblasts of specific lineages cannot be distinguished from each other. They are rare cells that are difficult distinguish from other types of cells (for example, large lymphocytes).
Promyelocytes of different granulocyte lineages cannot be distinguished from each other.
Neutrophilic Myelocyte
The neutrophilic promyelocyte matures into a neutrophilic myelocyte.
This is the first stage in which precursors of the different granulocyte lineages can be distinguished from each other because of the presence of specific granules.
Larger cells (18 to 20 µm diameter)
Round, oval or indented nucleus (50% of cell) with a coarser, granular pattern of chromatin
Mature neutrophils are released from bone marrow into the peripheral circulation. They circulate in blood for 8 to 16 hrs. Their tissue life span is only 1 to 2 days.
