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CHAPTER 14 - GASTROINTESTINAL TRACT
Histology Guide
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MICROGRAPH

NAME
EM 394 Paneth Cells
TISSUE
Small Intestine
IMAGE SIZE
8,668 x 11,106 pixels
289 MB
FILE SIZES
29,210 KB (grayscale)
36,114 KB (color)
MAGNIFICATION
Unknown
PIXEL SIZE
2.008 nm
SOURCE
Stanley L. Erlandsen
Department of Genetics, Cell Biology, and Development
University of Minnesota
Minneapolis, MN

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EM 394 Paneth Cells

Paneth Cells

Transmission electron microscopy (TEM) of the epithelium at the base of an intestinal gland (or crypt of Lieberkühn) in the small intestine.

Stem cells (orange) can self-renew and produce progenitor cells (tan), also known as transit-amplifying cells. These cells undergo rapid cell division and differentiate as they move up from the crypt to the villi. These include enterocytes, goblet cells, Paneth cells, and enteroendocrine cells.

Paneth cells (green) remain at the base of the crypts and secrete antimicrobial peptides and proteins, such as defensins, lysozyme, and phospholipase A2. They have large amounts of rough endoplasmic reticulum and large, electron-dense granules.

Paneth cells have long lifespans compared to other intestinal epithelial cells. They maintain close interactions with stem cells, providing crucial signals for maintaining and proliferation of these cells.

Subcellular Structures

  • Nucleus (blue) / Nucleolus (yellow) / Nuclear Envelope (purple)
  • Golgi Apparatus (yellow)
  • Mitochondria (red)
  • Endoplasmic Reticulum
  • Lysosomes (black)
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