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CHAPTER 15 - LIVER AND GALLBLADDER
Histology Guide
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MICROGRAPH

NAME
EM 353 Liver
TISSUE
Rat Liver
IMAGE SIZE
7,680 x 5,760 pixels
130 MB
FILE SIZES
19,493 (grayscale)
20,546 KB (color)
MAGNIFICATION
10,000x
PIXEL SIZE
1.667 nm
SOURCE
Edward N. Harris
Department of Biochemistry
University of Nebraska
Lincoln, NE

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EM 353 Liver

Hepatic Sinusoids

Scanning electron micrograph (TEM) of a sinusoid in the liver. Hepatic sinusoids (tan) are lined with a discontinuous endothelium with many small pores (or fenestrations) and gaps between neighboring endothelial cells.

The space between the endothelium and hepatocytes (green) is named the space of Disse. Microvilli project into this space from the basolateral surface of the hepatocytes.

Blood plasma easily flows from the sinusoids into the space Disse. The microvilli increase the surface area for the exchange of materials between plasma and hepatocytes. Plasma that collects in the space of Disse flows back to the portal triads collecting in lymphatic vessels.

Courtesy of Edward N. Harris, Department of Biochemistry, University of Nebraska, Lincoln, NE.

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