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CHAPTER 5 - CARTILAGE AND BONE
Histology Guide
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MICROSCOPE SLIDE

SLIDE NAME
MHS 242 Fetal Face
TISSUE
Fetal Face
STAIN
Hematoxylin & Eosin
IMAGE SIZE
33,900 x 35,200 pixels
4.4 GB
FILE SIZE
2.07 GB
OBJECTIVE
40x
PIXEL SIZE
0.3171 µm
SOURCE
T. Clark Brelje and Robert L. Sorenson
Department of Genetics, Cell Biology, and Development
School of Medicine
University of Minnesota
Minneapolis, MN

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Robert L. Sorenson, Ph.D.

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University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455

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MHS 242 Fetal Face

Intramembranous Bone Formation

This frontal section through the face of an embryo contains many examples of intramembranous bone formation. Bone is formed by the differentiation of mesenchymal cells into osteoblasts.

  • Mandible (, ) - examine the developing .
    • - cover the surface of bone spicules. Their basophilic cytoplasm is from the synthesis of proteins in osteoid (mostly type I collagen).
    • - unmineralized, organic portion (type I collagen and ground substance) of bone matrix. Narrow, light-pink region between osteoblasts and the bone spicule.
    • - osteoblasts trapped inside lacunae of bone.
  • Maxilla (, ) - developing bone spicules (, ).
  • Frontal (, ) - developing bone spicules (, ).

These spicules are examples of They contain randomly arranged type I collagen fibers within a more basophilic, mineralized osteoid.

Other interesting structures unrelated to intramembranous bone formation.

  • Merkel's Cartilage (, ) - occurs transiently in human embryos. It forms the jaw in cartilaginous fish.
  • Endochondral Bone Formation - the cartilaginous scaffold of the developing , ethmoid bone (, ) and nasal conchae (, ) are seen.
© 2005-2026. T. Clark Brelje and Robert L. Sorenson