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CHAPTER 5 - CARTILAGE AND BONE
Histology Guide
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MICROSCOPE SLIDE

SLIDE NAME
MH 136 Trachea
TISSUE
Trachea
(human)
STAIN
Hematoxylin & Eosin
IMAGE SIZE
98,277 x 38,688 pixels
14 GB
FILE SIZE
331 MB
OBJECTIVE
40x
PIXEL SIZE
0.3171 µm
SOURCE
Department of Genetics, Cell Biology, and Development
School of Medicine
University of Minnesota
Minneapolis, MN

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Robert L. Sorenson, Ph.D.

Professor Emeritus
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455

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MH 136 Trachea

Trachea in and .

What type of exists as C-shaped rings in the trachea? [ + ]

Hyaline cartilage

Describe the of this type of cartilage: [ + ]

Extensive extracellular matrix that separates a sparse population of chondrocytes within lacunae

Name of the predominant type of collagen: [ + ]

Collagen type II

What is the primary component of the ground substance? [ + ]

Glycosaminoglycans (GAGs) attached to proteoglycan core proteins that are linked together by long chains of hyaluronic acid

Why is cartilage so basophilic? [ + ]

Glycosaminoglycans (GAGs) are highly negatively charged due to many sulfate and carboxyl groups

What covers the external surface of hyaline cartilage? [ + ]

Perichondrium

Name of its and how do they differ? [ + ]

  • – type I collagen and fibroblasts
  • – type II collagen and chondroblasts

What is the precursor cell for chondroblasts? [ + ]

Mesenchymal cells

are found in what structures? [ + ]

Lacunae

What is meant by an isogenous group or cell nest? [ + ]

Chondrocytes that divided and occupy a single lacuna

What is the ? [ + ]

Matrix closest to chondrocytes enriched in glycosaminoglycans (GAGs)

Why is the interterritorial matrix less basophilic than territorial matrix? [ + ]

Lower amounts of glycosaminoglycans (GAGs) relative to the eosinophilic collagen type II fibrils

What accounts for the tensile strength of hyaline cartilage? [ + ]

Meshwork arrangement of collagen type II fibrils

What provides much of its resistance to compression? [ + ]

Large amounts of water bound to glycosaminoglycans (GAGs) that occupy a large volume relative to their mass

How do chondrocytes survive if is avascular? [ + ]

Nutrients and waste products diffuse through the hydrated matrix

How does appositional growth differ from interstitial growth? [ + ]

  • Appositional growth occurs through the addition of new cells derived from the chondrogenic layer of the perichondrium
  • Interstitial growth comes from the division of chondrocytes to form isogenous groups

Why does the calcification of cartilage lead to its death? [ + ]

Limits diffusion of nutrients and waste products causing cell death by apoptosis

Where can hyaline cartilage be found? [ + ]

  • Ends of long bones
  • Anterior ends of ribs
  • Nose
  • Supporting rings of respiratory passages
  • Precursor of bone at epiphyseal plates
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