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MH 126b Liver
The classic liver lobule is the traditional way to describe the organization of the liver parenchyma.
- individual lobules are seen as lighter areas with darker edges at low magnification
- roughly hexagonal structure with a central vein at its center and six portal triads at its periphery. (However, the random direction of a section makes this classical description rarely seen in a single profile.)
- large venule at the center of the lobule
- anastomosing plates, one cell thick, radiate outward from the central vein separated by sinusoidal capillaries and supported by reticular fibers. (In this specimen, the hepatocytes contain much lipofuscin.)
- at the corners of each lobule
Hepatic Arterioles - supply oxygen-rich blood to sinusoids
Portal Venule - supply nutrient-rich blood from the gastrointestinal tract to sinusoids
Bile Ductules - drain bile from hepatocytes to the periphery
Lymphatic Vessels - drain lymph from perisinusoidal spaces of Disse to the periphery
- lined with a simple cuboidal epithelium (longitudinal section, lumen is not visible)