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CHAPTER 1 - THE CELL
Histology Guide
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MICROSCOPE SLIDE

SLIDE NAME
MH 001 Nuclear Morphology
TISSUE
Lymph Node (monkey)
Spinal Cord, Ventral Horn (human)
Liver (monkey)
STAIN
Hematoxylin & Eosin
IMAGE SIZE
42,760 x 28,956 pixels
4.6 GB
FILE SIZE
1.3 GB
OBJECTIVE
40x
PIXEL SIZE
0.4666 µm
SOURCE
Department of Genetics, Cell Biology, and Development
School of Medicine
University of Minnesota
Minneapolis, MN

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University of Minnesota
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Robert L. Sorenson, Ph.D.

Professor Emeritus
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455

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MH 001 Nuclear Morphology

What are the two types of found in the nucleus? [ + ]

  • Heterochromatin - tightly packed form of DNA. Heterochromatic nuclei stain uniformly and intensely with hematoxylin. This is indicative of a cell with low transcriptional activity.
  • Euchromatin - lightly packed form of DNA. Euchromatic nuclei show random clumps of hematoxylin staining mostly at the periphery of the nucleus and the nucleolus. This is indicative of cells with high transcriptional activity.

Which component(s) of the nucleus stains intensely with basophilic dyes? [ + ]

Heterochromatin (DNA) and the nucleolus (RNA)

At high magnification, examine individual surrounding this capillary.

Nuclei of lymphocytes contain mostly:


What is the diameter of lymphocytes? [ + ]

6 to 10 µm

What does the small amount of cytoplasm suggest about these cells? [ + ]

They are not synthesizing much protein

The size of (i.e., fat cells) varies depending on the tissue.

What is the diameter of these adipocytes? [ + ]

30 to 60 µm

Describe nuclei of adipocytes: [ + ]

Round nuclei (8 to 10 µm diameter) at the periphery of the cells

Red blood cells can be used as cellular rulers to determine the size of other structures.

What is the diameter of ? [ + ]

7.5 µm

Examine the in this section of spinal cord.

What is the diameter of motor neurons? [ + ]

80 to 120 µm

What is the diameter of their nuclei? [ + ]

20 to 30 µm

What is the diameter of the smaller nuclei in nearby glial cells? [ + ]

6 to 10 µm

Examine the in this liver section.

Estimate the diameter of hepatocytes? [ + ]

∼30 µm

What is the diameter of their nuclei? [ + ]

∼10 µm
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