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CHAPTER 3 - CONNECTIVE TISSUE
Histology Guide
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MICROGRAPH

NAME
EM 111 Mast Cell
TISSUE
Connective Tissue
IMAGE SIZE
10,909 x 8,876 pixels
369 MB
FILE SIZES
20,252 KB (grayscale)
20,871 KB (color)
MAGNIFICATION
17,700
PIXEL SIZE
3.736 nm
SOURCE
Stanley L. Erlandsen
Department of Genetics, Cell Biology and Development
School of Medicine
University of Minnesota
Minneapolis, MN

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EM 118 Mast Cell

Mast Cell Degranulation

Anaphylaxis is a severe allergic reaction of rapid onset due to the release of inflammatory mediators or cytokines by mast cells and basophils.

The antigen that provokes the allergic reaction binds to IgE antibodies. antigen-bound IgE then activates receptors on mast cells and basophils. This triggers the rapid release of the contents from secretion granules.

Their inflammatory mediators subsequently increase dilation of blood vessels and the contraction of smooth muscle.

The mast cell has undergone anaphylactic degranulation.

  • (blue) / Nuclear Envelope (purple)
  • (purple) - large, round granules (0.5-1.5 µm in diameter)
  • (grayscale) - endocytosed excess surface/granule membrane
  • (red) - rather small compared to most cells
  • Endoplasmic Reticulum (green) - difficult to identify
  • Cytoplasm (green)
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